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2008 Eastern Kentucky Colonels Schedule
| Date | Time (ET) | Opponent | Result | Record |
| 08/28/2008 | 07:30 PM | at Cincinnati | L, 40-7 | 0-1-0 |
| 09/06/2008 | 06:00 PM | Western Ky | L, 37-13 | 0-2-0 |
| 09/13/2008 | 06:00 PM | Morehead State | W, 16-8 | 1-2-0 |
| 09/20/2008 | 06:00 PM | at Tennessee St | L, 34-20 | 1-3-0 |
| 09/27/2008 | 03:00 PM | Austin Peay | W, 13-10 | 2-3-0 |
| 10/04/2008 | 08:00 PM | at Tenn Tech | W, 33-12 | 3-3-0 |
| 10/11/2008 | 06:00 PM | Jacksonville St | W, 38-35 | 4-3-0 |
| 10/25/2008 | 03:00 PM | Eastern Ill | ||
| 11/01/2008 | 02:00 PM | at SE Missouri St | ||
| 11/15/2008 | 01:00 PM | Murray State | ||
| 11/22/2008 | 01:00 PM | at Tenn-Martin |
