The meeting is scheduled for Friday in Charlotte's Ballantyne area.
Known as neonicotinoids, advocates say the pesticide compounds are responsible for large honeybee die-offs. The group behind the protests, SumOfUs.org, also has various campaigns against other companies such as McDonald's and Facebook.
Lowe's spokeswoman Connie Bryant said the company is concerned about bee health and follows environmental studies about the effects of pesticides.
The protest, scheduled to precede the 10 a.m. shareholder meeting, is set to feature beekeepers and a giant inflatable bee.