Troopers said Stephen Moody, 42, and Kevin Moody, 19, were killed when Amie Jo Skeens' car hit their motorcycle on Airport Rhodhiss Road in Long View.
Police said Skeens crossed the center line and side-swiped another motorcycle first before crashing head-on into Moody's motorcycle.
SLIDESHOW: Scene of deadly motorcycle accident
WATCH: Woman accused in fatal hit-and-run makes first court appearance
The two on the first motorcycle were transported to the hospital with minor injuries.
Troopers arrested Skeens, 37, about a half-mile away, whose damaged car was parked down a dirt road.
Neighbors said they saw Skeens wandering through the woods. "She thought she was at her grandma's house," Josh Parkhurt said.
Skeens attempted to kick a Channel 9 reporter who was on the scene and tried to question her. Skeens did tell Channel 9 she was high on drugs, but not driving. "I couldn't have been driving. I was too high," she said.
Skeens has been charged with DWI and felony hit-and-run causing death. Police said she could face other charges as well.
Skeens was jailed with bail set at $30,000.
Skeens was convicted in 2006 for drug possession and in 1996 she was convicted of a crime again nature, both in Catawba County.
In court Wednesday morning, 37-year-old Skeens had a much different demeanor. Tears streamed down her face as she made her first appearance on DWI and felony hit-and-run charges.
Skeens told the judge she did not have a job and could not afford an attorney, so she was appointed one.
After her appearance, she ignored reporters outside the courtroom as she was ushered down a hallway by police. Two people who knew her were also in court, but they declined comment.
She is scheduled to make her next court appearance Nov. 16.