NBC and dick clark productions announced Friday the duo will sing "Medellin" at the May 1 event in Las Vegas.
The song, released on Wednesday, is from Madonna's 14th album "Madame X," out June 14. She said the Latin-flavored album was inspired from living in Lisbon, Portugal, for the last few years.
Maluma has had major success on the Latin charts since releasing his sophomore album, 2015's "Pretty Boy, Dirty Boy." The 25-year-old singer won his first Latin Grammy last year for "F.A.M.E." - also nominated for top Latin album at the Billboard Awards.
Other performers will include BTS, Halsey, Kelly Clarkson, Jonas Brothers, Sam Smith, Normani and Mariah Carey.
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