Team officials made the announcement about the 70-year-old Hall of Fame coach about 40 minutes before tipoff.
Associate head coach Jeff Capel is again running the team in his absence. Capel led the team for four weeks midway through last season after the winningest men's coach in Division I had back surgery.
The seventh-ranked Blue Devils (14-2, 2-2 Atlantic Coast Conference) are coming off an 87-52 rout at Pittsburgh and face a quick turnaround with a road game Monday night at No. 18 Miami.
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