Gustafson finished with 20 points, on 9-of-13 shooting, 10 rebounds and two blocks. Makenzie Meyer added 16 points, including four 3-pointers, and eight assists for Iowa (3-0) and freshman Monika Czinano scored a season-high 15.
The Hawkeyes, who never trailed, opened the second quarter with a 13-2 run to push its lead to 28 points and Gustafson made a layup early in the third quarter that sparked a 33-2 run that made it 84-24 with 6:58 to play. Tomi Taiwo's layup gave Iowa a 68-point lead with 1:32 remaining.
Lanay Rodney led NCCU (0-3) with seven points.
The Hawkeyes had a program-record 36 assists, breaking the old mark of 34 set in their 104-67 win at Western Kentucky on Tuesday. Iowa was a point shy of the school's single-game scoring record and has scored at least 90 points in each game this season.
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