News outlets reported the fire was reported around 4 a.m. Monday at Delorce's Bird Barn in Awendaw (AH-wen-daw) about 25 miles (40 kilometers) northeast of Charleston.
Awendaw-McClellanville Fire Battalion Chief Michael Bowers said there were between 200 and 400 birds in the building when the fire started.
The owner told reporters that some birds had died in the fire.
Bowers said most of the birds were in good condition and were being helped by Animal Protective Service officers.
There were no people in the building when the fire started and no firefighters were hurt.
The cause of the fire is under investigation.
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