LSU (35-22) faces No. 4 seed Mississippi State (45-11) on Wednesday in the first day of double-elimination competition. South Carolina (28-28) has been eliminated.
South Carolina scored five runs in the second inning off LSU starter Cole Henry to grab a 5-1 lead. LSU answered with two runs in the bottom of the second, three in the fourth and two in the fifth.
Devin Fontenot (5-1) pitched 4 1/3 innings of shutout relief and Cade Beloso went 3 of 4 and drove in three runs for LSU. Todd Peterson gave up one run in 2 2/3 innings to earn his third save.
South Carolina's Parker Coyne (2-1) allowed four runs in 1 2/3 innings.
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