Gamecocks coach Frank Martin said Friday that Moss will take a medical redshirt season. Moss is expected to make a complete recovery and return next season.
Moss suffered a right high ankle sprain and reaggravated a previous foot injury at practice on Dec. 18.
The 6-foot-2 guard from Memphis, Tennessee, played in seven games and started three in row against Coastal Carolina, Wyoming and No. 2 Michigan before getting hurt.
He played 20 minutes a game and averaged 6.3 points per contest. He had a season-best 12 points in a 76-67 loss to Providence in November.
The Gamecocks (7-7, 2-0 Southeastern Conference) host Missouri (9-4, 0-1).
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