A new review of research on Tylenol use during pregnancy finds no evidence of a causal link between the medication and neurodevelopmental disorders such as autism or ADHD.
Researchers reviewed seven meta-analyses involving more than 3 million participants. When all available studies were considered, there appeared to be small associations between prenatal acetaminophen exposure and autism and ADHD.
But when researchers focused on higher-quality studies and analyses, those associations were substantially reduced and approached zero. The researchers said the available evidence does not support a robust causal relationship.
The findings come amid ongoing debate over acetaminophen, the active ingredient in Tylenol, and pregnancy. In September 2025, the Trump administration raised concerns about a possible connection to autism and ADHD.
The American College of Obstetricians and Gynecologists has said the evidence does not support a causal link and continues to recommend acetaminophen as a first-line medication for pain and fever during pregnancy when used appropriately and in consultation with a health care professional.
Researchers also note that untreated fever and pain during pregnancy can pose health risks, making the risks and benefits of treatment an important consideration.
©2026 Cox Media Group
/cloudfront-us-east-1.images.arcpublishing.com/cmg/LH3JSJEF3VBLRJLJQESEAG34AM.png)
